Research: Keto diet enhances experimental cancer therapy in mice

A recent study investigated how a ketogenic diet (KD)—high in fats and low in carbohydrates—can enhance the effectiveness of an experimental anti-cancer drug in mice with pancreatic cancer. The research aimed to determine if combining dietary interventions with targeted therapies could more effectively inhibit tumour growth.

READ FULL ARTICLE

Key Findings:

1. Impact of the Ketogenic Diet on Tumour Growth:

   • Mice with pancreatic tumours were fed a ketogenic diet, leading to reduced blood glucose levels and increased ketone bodies.

   • Despite these changes, the ketogenic diet alone did not significantly slow tumour growth.

   
   

2. Combining Ketogenic Diet with eIF4E Inhibition:

   • The study focused on eIF4E, a protein that regulates gene activity and is often overactive in cancers.

   • Researchers used an experimental drug, eFT508 (tomivosertib), to inhibit eIF4E.

   • When administered alone, eFT508 did not markedly affect tumor growth.

   • However, combining the ketogenic diet with eFT508 significantly reduced tumour size in the mice.

   
   
   
   

---

If you are finding these resources helpful, consider a small donation to support the running costs of this website resource!

Buy Me a Coffee